Understand How Disease Disrupts the Body—and How We Make Sense of It

Pathophysiology is the study of disordered physiological processes that underlie disease. In this course, you’ll explore what happens when normal anatomy and function break down, and how these changes lead to the signs, symptoms, and complications seen in real clinical settings.

This course doesn’t just describe diseases—it explains them from the inside out. You’ll uncover the mechanisms behind cellular injury, inflammation, immune dysfunction, and organ system failure. By mastering how and why disease develops, you’ll lay the foundation for effective clinical reasoning, diagnostics, and treatment strategies.

Created by medical students and reviewed by clinicians, these high-yield notes and explanations are crafted to help you understand pathology rather than just memorize it. Ideal for medical, nursing, and allied health students, this course bridges the gap between physiology and clinical practice.

Course Contents

Cardiovascular System

  • Atherosclerosis and ischemic heart disease
  • Hypertension and hypertensive organ damage
  • Heart failure: left vs right, forward vs backward
  • Shock: hypovolemic, cardiogenic, distributive
  • Arrhythmias and valvular disorders

Respiratory System

  • Asthma, COPD, emphysema, chronic bronchitis
  • Pneumonia and lung infections
  • ARDS and restrictive lung disease
  • Pulmonary embolism and pulmonary hypertension

Renal System

  • Acute and chronic kidney injury
  • Glomerulonephritis and nephrotic/nephritic syndromes
  • Electrolyte and acid-base imbalances
  • Urinary tract obstruction and infections

Gastrointestinal System

  • GERD, peptic ulcer disease, and H. pylori
  • Inflammatory bowel diseases (Crohn’s, ulcerative colitis)
  • Liver diseases (hepatitis, cirrhosis, portal hypertension)
  • Pancreatitis and malabsorption syndromes

Endocrine System

  • Diabetes mellitus (Type 1 and Type 2)
  • Thyroid disorders (hypo/hyperthyroidism, Graves’, Hashimoto’s)
  • Adrenal dysfunction (Cushing’s, Addison’s, pheochromocytoma)
  • Parathyroid and calcium homeostasis disorders

Nervous System

  • Stroke and cerebral ischemia
  • Seizures and epilepsy
  • Multiple sclerosis and demyelination
  • Neurodegenerative diseases (Alzheimer’s, Parkinson’s)
  • Increased intracranial pressure and herniation

Hematologic System

  • Anemias (iron deficiency, B12/folate, hemolytic)
  • Leukemias and lymphomas
  • Coagulation disorders (hemophilia, DIC, thrombocytopenia)

Musculoskeletal System

  • Osteoarthritis vs rheumatoid arthritis
  • Gout and crystal-induced arthropathies
  • Bone metabolism disorders (osteoporosis, Paget’s disease)
  • Muscular dystrophies and inflammatory myopathies

Reproductive & Breast Pathophysiology

  • Prostate pathologies and testicular tumors
  • Menstrual cycle disorders and infertility
  • PCOS, endometriosis, and ovarian pathologies
  • Breast cancer and benign breast diseases